Description

1-Chloromethyl-3,3-Dimethyl-3,4-Dihydro-Isoquinoline is a versatile and high-value heterocyclic building block, specifically a functionalized isoquinoline derivative. This compound is critical for its role as a key synthetic intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as medicinal chemistry and the synthesis of fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing alkaloid-like structures.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the isoquinoline scaffold can contribute to biological activity.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the manufacture of dyes, pigments, and other performance chemicals that require complex nitrogen-containing heterocycles.
• Academic and Industrial Research: A valuable reagent for methodological studies in organic chemistry, including cyclization and functional group transformation reactions.
• Material Science Precursor: Potential use in the synthesis of organic semiconductors or conductive polymers due to its electron-rich aromatic system.

Basic Information

Product Name	1-Chloromethyl-3,3-Dimethyl-3,4-Dihydro-Isoquinoline
CAS No.	146304-90-7
Molecular Formula	C12H14ClN
Molecular Weight	207.70 g/mol
Synonyms	1-(Chloromethyl)-3,3-dimethyl-3,4-dihydroisoquinoline; 3,4-Dihydro-3,3-dimethyl-1-isoquinolinecarboxaldehyde Chloride (related); 1-Chloromethyl-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline; 3,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline-1-carbaldehyde Chloride; 1-Chloromethyl-3,3-dimethyl-3,4-dihydro-isoquinoline; 146304-90-7; Isoquinoline, 3,4-dihydro-1-(chloromethyl)-3,3-dimethyl-
EINECS	Contact for details

Quality Control

Our 1-Chloromethyl-3,3-Dimethyl-3,4-Dihydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.