Description

6-Iodo-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-value, halogenated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and functional materials, enabling critical carbon-iodine bond transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a versatile scaffold for developing new generation herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the synthesis of organic semiconductors, liquid crystals, and photoactive materials for electronic applications.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form new carbon-carbon bonds.
• Functional Group Transformation: The ester group can be hydrolyzed to the corresponding carboxylic acid or reduced to the alcohol, enabling further derivatization.
• Ligand Synthesis: Potential building block for creating novel ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	6-Iodo-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	146137-94-2
Molecular Formula	C10H7IO2S
Molecular Weight	318.13 g/mol
Synonyms	Methyl 6-Iodobenzo[b]thiophene-2-carboxylate; 6-Iodobenzo[b]thiophene-2-carboxylic Acid Methyl Ester; Benzo[b]thiophene-2-carboxylic acid, 6-iodo-, methyl ester; Methyl 6-iodo-1-benzothiophene-2-carboxylate; 2-Methoxycarbonyl-6-iodobenzo[b]thiophene; 6-Iodo-2-(methoxycarbonyl)benzo[b]thiophene
EINECS	Contact for details

Quality Control

Our 6-Iodo-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to air and moisture during use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.