Description

5-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-value fluorinated heterocyclic building block, prized for its unique electronic and steric properties imparted by the trifluoromethyl and benzo[b]thiophene motifs. This compound is essential for medicinal chemistry and advanced materials research, enabling the synthesis of novel molecules with enhanced metabolic stability and lipophilicity. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to create advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for organic semiconductors, liquid crystals, and other functional fluorinated materials.
• Chemical Biology: Employed as a probe or tag in biochemical assays due to its distinctive fluorine NMR signature.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	5-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	146137-92-0
Molecular Formula	C11H7F3O2S
Molecular Weight	260.23 g/mol
Synonyms	Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid methyl ester; 2-Methoxycarbonyl-5-trifluoromethylbenzo[b]thiophene; 5-Trifluoromethylbenzothiophene-2-carboxylic acid methyl ester; 146137-92-0; Methyl 5-trifluoromethyl-1-benzothiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of 5-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.