Description

Tiagabine Hydrochloride is a high-purity, fine chemical compound primarily used as a potent and selective GABA reuptake inhibitor. This active pharmaceutical ingredient (API) is critical for the development and manufacturing of neurological and psychiatric medications. It is essential for pharmaceutical companies and research institutions focused on anticonvulsant therapies and central nervous system (CNS) disorder research. Our supply ensures consistent quality and reliable availability for global pharmaceutical production.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of anticonvulsant and antiepileptic medications.
• Neurological Research: A key compound in preclinical and clinical studies targeting GABAergic systems for conditions like epilepsy and neuropathic pain.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Formulation Development: Used in R&D for developing new dosage forms, including tablets and capsules.
• Biochemical Studies: Employed in vitro and in vivo studies to investigate synaptic transmission and neurotransmitter regulation.

Basic Information

Product Name	Tiagabine Hydrochloride
CAS No.	145821-59-6
Molecular Formula	C20H25NO2S2 • HCl
Molecular Weight	412.02 g/mol
Synonyms	Tiagabine HCl; (R)-(-)-Tiagabine Hydrochloride; (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]nipecotic Acid Hydrochloride; Gabitril (trade name); NNC-05-0328; Nipecotic Acid Butyl Ester, Hydrochloride; NO-05-0328
EINECS	Contact for details

Quality Control

Our Tiagabine Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) is available for every lot, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	-15.0° to -18.0° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.