Description

Tiagabine Hydrochloride is a high-purity, synthetically derived active pharmaceutical ingredient (API) primarily used as a potent and selective GABA reuptake inhibitor. Its core value proposition lies in providing reliable, consistent quality for the formulation of critical neurological medications. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing treatments for epilepsy and related central nervous system disorders. We supply Tiagabine Hydrochloride CAS NO 145821-57-4 to the global market with a commitment to stringent quality control and supply chain integrity.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antiepileptic drugs.
• Neurological Research: Critical reagent in preclinical and clinical studies investigating GABAergic neurotransmission and seizure mechanisms.
• Formulation Development: Used in R&D for developing new dosage forms such as tablets, capsules, and controlled-release formulations.
• Reference Standard: Serves as a high-purity chemical standard for analytical method development and quality control testing in pharmaceutical labs.
• Generic Drug Manufacturing: Key starting material for the production of generic versions of GABA reuptake inhibitor medications.
• Biochemical Studies: Utilized in vitro studies to understand the specific inhibition of GABA transporter GAT-1.

Basic Information

Product Name	Tiagabine Hydrochloride
CAS No.	145821-57-4
Molecular Formula	C20H25NO2S2·HCl
Molecular Weight	412.02 g/mol
Synonyms	Tiagabine HCl; (R)-(-)-Tiagabine Hydrochloride; N-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]nipecotic Acid Hydrochloride; Gabitril (trade name); GAT-1 Inhibitor; NO-328; AHR-12924; (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Tiagabine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, with typical purity levels exceeding 99.0%. Testing includes identity confirmation, assay, impurity profiling (including related substances and residual solvents), and specific tests for chiral purity. Certificates of Analysis (COA) documenting full compliance with agreed specifications are provided with each shipment. Our quality commitment aligns with ICH guidelines and supports regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Individual unknown impurity ≤ 0.10% Total impurities ≤ 0.50%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.