Description

(5R,6S)-Benzyl 3-(Dimethoxyphosphoryl)-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate is a high-purity, stereochemically defined organic intermediate of significant interest in advanced synthetic chemistry. This compound matters for its role as a key building block in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting complex enzymatic pathways. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to facilitate the synthesis of potential drug candidates with specific chiral configurations.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-infective agents.
• Asymmetric Synthesis: Used as a precursor or auxiliary in stereoselective synthesis to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the creation of focused compound libraries for biological screening.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs during pre-clinical and clinical development phases.
• Organophosphorus Chemistry: Acts as a valuable substrate for studying phosphorylation reactions and developing new organophosphorus compounds with potential biological activity.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological development in organic synthesis and catalysis.

Basic Information

Product Name	(5R,6S)-Benzyl 3-(Dimethoxyphosphoryl)-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate
CAS No.	145761-32-6
Molecular Formula	C26H26NO7P
Molecular Weight	495.46 g/mol
Synonyms	Benzyl (5R,6S)-3-(dimethoxyphosphoryl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate; 4-Carboxy-2-oxo-5,6-diphenylmorpholine-3-phosphonic acid dimethyl ester benzyl ester; (5R,6S)-Benzyl 3-(dimethoxyphosphoryl)-2-oxo-5,6-diphenyl-4-morpholinecarboxylate; 145761-32-6; (5R,6S)-rel-Benzyl 3-(dimethoxyphosphoryl)-2-oxo-5,6-diphenylmorpholine-4-carboxylate; Morpholine-4-carboxylic acid, 3-(dimethoxyphosphinyl)-2-oxo-5,6-diphenyl-, benzyl ester, (5R,6S)-
EINECS	Contact for details

Quality Control

Our (5R,6S)-Benzyl 3-(Dimethoxyphosphoryl)-2-Oxo-5,6-Diphenylmorpholine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.