Description

5-(2-Bromo-Acetyl)-Thiophene-2-Carboxylic Acidethyl Ester CAS NO 145739-67-9 is a high-purity, versatile heterocyclic building block, specifically a thiophene derivative functionalized with bromoacetyl and ester groups. This compound is critically important for its dual reactivity, enabling its use as a key intermediate in the synthesis of complex molecules for pharmaceutical and advanced material research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products, leveraging its reactive bromoacetyl moiety.
• Material Science Research: Serves as a precursor for creating functionalized polymers or organic electronic materials due to the thiophene backbone.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex molecular architectures.
• Heterocyclic Chemistry: A fundamental starting material for the synthesis of more complex fused or substituted thiophene-containing heterocycles.

Basic Information

Item	Details
Product Name	5-(2-Bromo-Acetyl)-Thiophene-2-Carboxylic Acidethyl Ester
CAS No.	145739-67-9
Molecular Formula	C9H9BrO3S
Molecular Weight	277.14 g/mol
Synonyms	Ethyl 5-(2-bromoacetyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-(2-bromoacetyl)-, ethyl ester; 5-(2-Bromoacetyl)thiophene-2-carboxylic acid ethyl ester; Ethyl 5-(bromoacetyl)thiophene-2-carboxylate; 5-(Bromoacetyl)thiophene-2-carboxylic Acid Ethyl Ester; 145739-67-9; AKOS BRN-0791
EINECS	Contact for details

Quality Control

Our 5-(2-Bromo-Acetyl)-Thiophene-2-Carboxylic Acidethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.