Description

(S)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant synthetic value. This compound is essential for the efficient construction of complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for process development and commercial-scale production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of biologically active compounds and complex drug molecules.
• Asymmetric Synthesis: Used as a versatile building block for constructing stereogenic centers in medicinal chemistry and total synthesis projects.
• API Development: Serves as a critical precursor in the research and development of new Active Pharmaceutical Ingredients (APIs).
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals and complex organic compounds.
• Agrochemical Research: Utilized in the development of novel chiral pesticides and herbicides.
• Catalyst & Ligand Synthesis: Acts as a starting material for the preparation of novel chiral catalysts and ligands.

Basic Information

Product Name	(S)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	145525-27-5
Molecular Formula	C15H17NO3
Molecular Weight	259.30 g/mol
Synonyms	(S)-2-(tert-Butoxycarbonyl)-3,4-dihydro-3-formylisoquinoline; (S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxaldehyde; (S)-N-Boc-3-formyl-1,2,3,4-tetrahydroisoquinoline; (S)-3-Formyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl (S)-3-formyl-3,4-dihydro-1H-isoquinoline-2-carboxylate; (S)-Boc-3-formyl-THIQ
EINECS	Contact for details

Quality Control

Our (S)-3-Formyl-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere to prevent oxidation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.