Description

(2R,3As,7As)-Octahydro-1H-Indole-2-Carboxylic Acid is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. Its rigid, fused bicyclic structure makes it a valuable scaffold for constructing complex molecules with precise three-dimensional architecture. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Asymmetric Synthesis: Employed as a precursor or catalyst ligand in stereoselective reactions to introduce complex chiral centers.
• Peptidomimetics & Constrained Peptide Design: Its indoline carboxylic acid structure serves as a proline analog or rigid backbone element in designing bioactive peptides with enhanced stability and selectivity.
• Agrochemical Research: Used in the synthesis of novel, chiral pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Material Science: Potential application as a monomer or functional additive in the synthesis of specialty polymers with unique optical or mechanical properties.
• Academic & Process Chemistry: A valuable reference standard and starting material for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	(2R,3As,7As)-Octahydro-1H-Indole-2-Carboxylic Acid
CAS No.	145513-91-3
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(2R,3aR,7aR)-Octahydro-1H-Indole-2-Carboxylic Acid; (2R,3aR,7aR)-Octahydroindole-2-carboxylic acid; (2R,3aR,7aR)-2-Carboxyhexahydro-1H-indole; cis-(3aR,7aR)-Octahydro-1H-indole-2-carboxylic acid; (2R,3aR,7aR)-Indoline-2-carboxylic acid (octahydro-); (2R,3aR,7aR)-2-Indolinecarboxylic acid; (2R,3aR,7aR)-Perhydroindole-2-carboxylic acid; (2R,3aR,7aR)-Amino acid building block
EINECS	Contact for details

Quality Control

Our (2R,3As,7As)-Octahydro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with each shipment to guarantee consistent quality and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.