Description

1H-Indole-2-Carboxylicacid,Octahydro-,[2R-(2-α-,3A-Bta-,7A-α-)]-(9Ci) is a high-purity, stereochemically defined octahydroindole-2-carboxylic acid derivative. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex bioactive molecules. It is essential for research and development in medicinal chemistry, particularly for organizations focused on creating novel therapeutics targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent drug candidates, especially those with complex polycyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with potential biological activity.
• Asymmetric Synthesis: Employed as a rigid, stereodefined scaffold for constructing enantiomerically pure compounds in process chemistry and development.
• Peptidomimetics Development: The indole carboxylic acid core is valuable for designing and synthesizing novel peptidomimetic compounds that mimic peptide function.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research institutions for custom synthesis projects and proprietary development pipelines.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1H-Indole-2-Carboxylicacid,Octahydro-,[2R-(2-α-,3A-Bta-,7A-α-)]-(9Ci)
CAS No.	145438-95-5
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(2R,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid; (2R,3aS,7aS)-2-Carboxyhexahydro-1H-indole; (2R,3aS,7aS)-Hexahydro-1H-indole-2-carboxylic acid; (2R,3aS,7aS)-Octahydroindole-2-carboxylic acid; (2R,3aS,7aS)-Perhydroindole-2-carboxylic acid; (2R)-Octahydro-1H-indole-2-carboxylic acid; Stereoisomer of Octahydroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced intermediates. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are provided, detailing specifications such as chiral purity (enantiomeric excess), chemical purity (HPLC), and residual solvent content. We support development and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment to prevent degradation and absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.