Description

(2S,3Ar,7As)-Octahydro-1H-Indole-2-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a rigid, fused bicyclic structure. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecules with precise stereochemistry for advanced research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutics, particularly peptidomimetics and constrained peptide analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Design: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability, bioavailability, and receptor selectivity in drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or a starting material for the synthesis of other enantiomerically pure compounds in academic and industrial laboratories.
• Biochemical Research: Utilized as a standard or probe in studies investigating enzyme inhibition, receptor-ligand interactions, and structure-activity relationships (SAR).
• Fine Chemical Production: Incorporated into the manufacture of specialty chemicals, catalysts, and advanced materials requiring high stereochemical purity.

Basic Information

Product Name	(2S,3Ar,7As)-Octahydro-1H-Indole-2-Carboxylic Acid
CAS No.	145438-94-4
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(2S,3aR,7aS)-Octahydro-1H-indole-2-carboxylic acid; (2S,3aR,7aS)-2-Carboxyhexahydro-1H-indole; cis-Octahydroindole-2-carboxylic acid; (2S,3aR,7aS)-Perhydroindole-2-carboxylic acid; OHIC; cis-OHICA; (2S,3aR,7aS)-1,2,3,3a,4,5,6,7a-Octahydroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2S,3Ar,7As)-Octahydro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet the highest standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.