Description

6',7'-Dihydroxybergamottin is a key furanocoumarin compound, a natural constituent found in grapefruit and other citrus species. This bioactive molecule is of significant commercial and research interest due to its potent inhibitory effects on the cytochrome P450 enzyme system, particularly CYP3A4. It is primarily sought after by the pharmaceutical, nutraceutical, and research sectors for applications in drug interaction studies, dietary supplement formulation, and as a reference standard in analytical chemistry.

Application

• Pharmaceutical Research & Development: Critical as a reference standard and active agent in studies of drug-drug and drug-food interactions, specifically investigating CYP3A4-mediated metabolism.
• Nutraceutical & Dietary Supplement Formulation: Used as a key bioactive ingredient in supplements targeting metabolic support, leveraging its natural enzyme-modulating properties.
• Analytical Chemistry & Quality Control: Serves as a high-purity certified reference material (CRM) for the identification, assay, and impurity profiling of related compounds in raw materials and finished products.
• Cosmeceutical Research: Investigated for potential applications in topical formulations due to its photobiological properties as a furanocoumarin.
• Academic & Biochemical Research: Employed in enzymology studies to understand the inhibition mechanisms of cytochrome P450 enzymes and their physiological impacts.

Basic Information

Product Name	6',7'-Dihydroxybergamottin
CAS No.	145414-76-2
Molecular Formula	C21H22O6
Molecular Weight	370.40 g/mol
Synonyms	6',7'-DHB; Dihydroxybergamottin; Bergamottin, 6',7'-dihydroxy-; 5-[(3,7-Dimethyl-2,6-octadienyl)oxy]-6,7-furano-5-hydroxycoumarin; 6',7'-Epoxybergamottin; GF-I-1; NSC 326334; Grapefruit furanocoumarin
EINECS	Contact for details

Quality Control

Our 6',7'-Dihydroxybergamottin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, assay, and results of all specified tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.