Description

2-[(tert-Butyldiphenylsilyloxy)Methyl]-1,3-Dioxolan-4-One is a high-value, protected synthetic intermediate widely used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise control over stereochemistry and functional group manipulation in complex molecule construction. It is primarily utilized by the pharmaceutical, agrochemical, and fine chemical industries for the development of active pharmaceutical ingredients (APIs), chiral catalysts, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug candidates, particularly for introducing chiral centers and protected alcohol functionalities.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, fragrances, and advanced polymer monomers.
• Academic & R&D Laboratories: Employed in methodological development and total synthesis projects for natural products and novel organic compounds.
• Chiral Auxiliary/Reagent: Functions as a reagent for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Process Chemistry: Integrated into scalable manufacturing routes for commercial products, valued for its stability and predictable reactivity.

Basic Information

Product Name	2-[(tert-Butyldiphenylsilyloxy)Methyl]-1,3-Dioxolan-4-One
CAS No.	145397-22-4
Molecular Formula	C20H24O4Si
Molecular Weight	356.49 g/mol
Synonyms	4-Oxido-1,3-dioxolan-2-ylmethyl tert-butyl(diphenyl)silane; 2-[(TBDPSO)Methyl]-1,3-dioxolan-4-one; (4-Oxo-1,3-dioxolan-2-yl)methyl tert-butyl(diphenyl)silanyl ether; TBDPS-protected glyceraldehyde acetonide; tert-Butyl(diphenyl)[(4-oxo-1,3-dioxolan-2-yl)methoxy]silane; 1,3-Dioxolan-4-one, 2-[(tert-butyldiphenylsilyloxy)methyl]-
EINECS	Contact for details

Quality Control

Our 2-[(tert-Butyldiphenylsilyloxy)Methyl]-1,3-Dioxolan-4-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials undergo rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.