Description

4-Bromo-2,5-difluoroiodobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and iodine substituents, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and the development of novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex biaryl and heteroaryl structures via Suzuki, Stille, or other metal-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the difluoro and halogenated benzene core imparts specific biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating halogenated aromatic cores used in the synthesis of advanced electronic materials for displays and lighting.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized ligands for catalysis and organometallic complexes.
• Chemical Biology Probes: Useful for incorporating halogen atoms into molecules used as probes or tags in biochemical and diagnostic research.
• Polymer Modification: Acts as a monomer or modifier in the synthesis of specialty polymers with unique electronic or physical properties.

Basic Information

Product Name	4-Bromo-2,5-Difluoroiodobenzene
CAS No.	145349-66-2
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	1-Bromo-4-iodo-2,5-difluorobenzene; 2,5-Difluoro-4-bromoiodobenzene; Benzene, 1-bromo-4-iodo-2,5-difluoro-; 4-Iodo-1-bromo-2,5-difluorobenzene; 4-Bromo-1-iodo-2,5-difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,5-difluoroiodobenzene is produced and tested under strict quality management protocols to ensure consistency and high purity for research and development applications. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.