Description

2-[4-[2-Hydroxy-3-(tert-Butylamino)Propoxy]-1H-Indol-3-Yl]-n-(Propan-2 -Ylideneamino)Acetamide Hydrochloride is a high-purity, non-racemic synthetic intermediate of significant pharmaceutical importance. Its complex molecular architecture, featuring an indole core linked to a propan-2-ylideneamino acetamide moiety via a hydroxypropoxy chain, makes it a critical building block for advanced research and development. This compound is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly those targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of potential drug candidates, especially in central nervous system (CNS) and cardiovascular research.
• Biochemical Research: Used as a reference standard or a probe molecule in pharmacological studies to investigate receptor-ligand interactions and enzyme inhibition.
• Process Chemistry Development: Employed in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and medicinal chemistry projects.
• Custom Synthesis: Acts as a starting material for contract research organizations (CROs) and CDMOs to produce bespoke compounds for client-specific programs.

Basic Information

Product Name	2-[4-[2-Hydroxy-3-(tert-Butylamino)Propoxy]-1H-Indol-3-Yl]-n-(Propan-2 -Ylideneamino)Acetamide Hydrochloride
CAS No.	145296-57-7
Molecular Formula	C22H33ClN4O3
Molecular Weight	437.0 g/mol (approx.)
Synonyms	2-[4-[2-Hydroxy-3-(tert-Butylamino)Propoxy]-1H-Indol-3-Yl]-N-(propan-2-ylideneamino)acetamide hydrochloride; (S)-2-[4-[2-Hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]-1H-indol-3-yl]-N-(1-methylethylidene)acetamide hydrochloride; Carvedilol Impurity 21; Carvedilol Related Compound H; Carvedilol EP Impurity H; (S)-Carvedilol Impurity 21; UNII-1J2Q8Q3W1D
EINECS	Contact for details

Quality Control

Every batch of this advanced pharmaceutical intermediate is produced and controlled under a strict quality management system. We provide comprehensive analytical data to support your regulatory filings, including HPLC purity, chiral purity, and identification by spectroscopic methods (IR, NMR, MS). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with client specifications or relevant pharmacopeial standards (e.g., USP, EP). Our quality commitment ensures material traceability and consistency for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.