Description

Secobarbital-D5 is a deuterated analog of the barbiturate derivative secobarbital, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in complex matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and clinical research sectors who require precise measurement and validation of secobarbital levels.

Application

• Internal Standard for Mass Spectrometry (MS): Primary application as a stable, non-interfering reference compound in LC-MS/MS and GC-MS methods for the quantification of secobarbital.
• Pharmaceutical Research & Development: Used in pharmacokinetic studies, metabolism research, and bioanalytical method development for barbiturate-class drugs.
• Forensic and Clinical Toxicology: Enables accurate identification and quantification of secobarbital in biological samples (e.g., blood, urine) for diagnostic and legal purposes.
• Drug Impurity Profiling: Assists in the analysis and characterization of related substances and degradation products in drug substances and products.
• Reference Material for Calibration: Serves as a certified reference material to calibrate analytical instruments and validate testing procedures.
• Regulatory Compliance Testing: Supports testing protocols to meet standards set by agencies like the FDA and EMA for drug safety and efficacy.

Basic Information

Product Name	Secobarbital-D5
CAS No.	145243-97-6
Molecular Formula	C12H13D5N2O3
Molecular Weight	243.30 g/mol (approx.)
Synonyms	5-Allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione-d5; Secobarbital (methyl-d3, allyl-d2); Deuterated Secobarbital; Secobarbital-d5 Internal Standard; 5-(1-Methylbutyl)-5-(2-propen-1-yl-2,3,3-d3)-2,4,6(1H,3H,5H)-pyrimidinetrione-1,3-d2; Quinalbarbitone-D5
EINECS	Contact for details

Quality Control

Every batch of Secobarbital-D5 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a high-grade reference standard. Certificates of Analysis (COA) are supplied with each shipment, detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality commitment ensures the material is suitable for the most demanding analytical applications, including GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.