Description

Triazolam-D4 is a deuterated analog of the pharmaceutical compound triazolam, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex matrices. It is primarily utilized by research scientists, analytical laboratories, and pharmaceutical quality control departments engaged in method development, pharmacokinetic studies, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS and GC-MS: Serves as a critical reference compound for the precise quantification of triazolam in biological samples (e.g., plasma, urine, tissue).
• Pharmaceutical Research & Development: Used in method validation, stability studies, and metabolism investigations to ensure data integrity.
• Forensic and Clinical Toxicology: Enables accurate measurement of triazolam levels for diagnostic and legal purposes.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates studies on the absorption, distribution, metabolism, and excretion (ADME) of triazolam.
• Quality Control in Pharmaceutical Manufacturing: Assays and verifies the content and purity of triazolam in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Reference Material for Regulatory Submissions: Provides the traceable standards required for compliance with FDA, EMA, and other global regulatory guidelines.

Basic Information

Product Name	Triazolam-D4
CAS No.	145225-04-3
Molecular Formula	C17H8D4Cl2N4
Molecular Weight	347.20 g/mol (deuterated form)
Synonyms	8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-d4; Triazolam (phenyl-d4); Triazolam-d4 (methyl-d3, phenyl-d4); Deuterated Triazolam; Triazolam Internal Standard; Triazolam-d4 Isotopic Label; [1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-d4 derivative
EINECS	Contact for details

Quality Control

Every batch of Triazolam-D4 is manufactured and tested under strict quality management systems to ensure it meets the exacting standards required for analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity, chemical purity, and absence of interfering impurities. Our quality commitment aligns with the needs of GMP/GLP-compliant laboratories, supporting reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.