Description

Oxymorphone-D3 is a deuterated internal standard of the potent opioid analgesic oxymorphone, specifically designed for analytical applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex matrices. It is primarily used by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development, validation, and routine testing.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of oxymorphone in biological samples (e.g., plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug concentration over time and the identification of metabolites in clinical and pre-clinical research.
• Forensic Toxicology: Used in confirmatory testing for oxymorphone in forensic investigations, ensuring legally defensible results through isotope dilution mass spectrometry.
• Pharmaceutical Quality Control: Supports the analysis of drug substance and finished product purity, stability, and impurity profiling in GMP environments.
• Method Development & Validation: Provides a stable isotopic reference for developing robust, sensitive, and selective analytical methods compliant with ICH and FDA guidelines.
• Doping Control: Applied in sports anti-doping programs for the sensitive detection of prohibited opioid substances.

Basic Information

Product Name	Oxymorphone-D3
CAS No.	145225-03-2
Molecular Formula	C17H16D3NO4
Molecular Weight	304.35 g/mol (approx.)
Synonyms	14-Hydroxydihydromorphinone-D3; 4,5α-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one-D3; Deuterated Oxymorphone; Oxymorphone-d3; Oxymorphone Internal Standard; Numorphan-D3; Opana-D3
EINECS	Contact for details

Quality Control

Every batch of Oxymorphone-D3 is manufactured and tested to meet the stringent requirements of analytical reference standard applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic techniques, to ensure high chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (NMR/MS), and related substances are provided and traceable to internally certified reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.