Description

(+/-)-Amphetamine-D8 CAS NO 145225-00-9 is a stable isotope-labeled analog of amphetamine, where eight hydrogen atoms are replaced with deuterium. This compound is critically important as an internal standard in quantitative analytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based measurements. It is primarily required by analytical laboratories, forensic science institutions, and pharmaceutical R&D departments engaged in drug metabolism studies, pharmacokinetic research, and substance abuse testing.

Application

• Internal Standard for LC-MS/MS and GC-MS: Essential for the precise quantification of amphetamine and its metabolites in complex biological matrices.
• Forensic Toxicology: Used in confirmatory testing and method validation for the detection of amphetamines in legal and workplace drug screening programs.
• Pharmaceutical Research: Facilitates drug metabolism and pharmacokinetic (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• Clinical Research: Supports studies investigating the pharmacodynamics of stimulant medications and research into substance use disorders.
• Reference Material: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating testing procedures.
• Metabolite Tracing: Enables the tracking and identification of deuterium-labeled metabolites in in vitro and in vivo studies.

Basic Information

Item	Detail
Product Name	(+/-)-Amphetamine-D8
CAS No.	145225-00-9
Molecular Formula	C9H5D8N
Molecular Weight	143.26 g/mol
Synonyms	DL-Amphetamine-D8; (±)-Amphetamine-D8; 1-Phenyl-2-aminopropane-D8; α-Methylphenethylamine-D8; Benzedrine-D8; Racemic Amphetamine-D8; Deutetrated Amphetamine; Amphetamine-d8 (heptadeuterated)
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Amphetamine-D8 is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, which is non-negotiable for its role as an analytical standard. Our quality control includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% chemical purity and ≥99% isotopic enrichment), and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.