Description

.Alpha.-Linolenic Acid-D5 CAS NO 145191-04-4 is a stable isotope-labeled analog of α-linolenic acid (ALA), an essential ω-3 fatty acid, where five hydrogen atoms are replaced by deuterium. This compound is a critical internal standard for the precise quantification of ALA in complex biological matrices using mass spectrometry. It is indispensable for researchers and quality control laboratories in the pharmaceutical, nutraceutical, and life science sectors who require high accuracy in metabolic studies, clinical diagnostics, and product formulation analysis.

Application

• Quantitative Mass Spectrometry: Serves as a deuterated internal standard for the accurate LC-MS/MS and GC-MS analysis of endogenous α-linolenic acid levels in plasma, serum, and tissue samples.
• Clinical Research & Diagnostics: Enables precise measurement of ω-3 fatty acid status in nutritional studies, cardiovascular disease research, and metabolic disorder investigations.
• Pharmaceutical Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drugs targeting lipid metabolism or requiring fatty acid co-administration.
• Nutraceutical & Food Science: Essential for the quality control and potency verification of ω-3 supplements, functional foods, and infant formulas.
• Metabolic Pathway Tracing: Facilitates advanced stable isotope tracer studies to elucidate the biosynthesis and conversion pathways of polyunsaturated fatty acids in vivo.
• Reference Material Production: Acts as a certified component in the preparation of high-purity reference materials and calibration standards for analytical laboratories.

Basic Information

Product Name	.Alpha.-Linolenic Acid-D5
CAS No.	145191-04-4
Molecular Formula	C18H25D5O2
Molecular Weight	283.45 g/mol (approx.)
Synonyms	(9Z,12Z,15Z)-Octadeca-9,12,15-trienoic-16,16,17,17,18,18,18-d7 acid (common IUPAC); all-cis-9,12,15-Octadecatrienoic-16,16,17,17,18,18,18-d7 acid; ALA-d5; Linolenic Acid-d5; 9,12,15-Octadecatrienoic-16,16,17,17,18,18,18-d7 acid; (Z,Z,Z)-9,12,15-Octadecatrienoic-16,16,17,17,18,18,18-d7 acid; Deuterated α-Linolenic Acid; ω-3 Fatty Acid-d5
EINECS	Contact for details

Quality Control

Our .Alpha.-Linolenic Acid-D5 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, solutions should be prepared in appropriate, degassed solvents and kept frozen. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98% (by MS)
Chemical Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO, chloroform; slightly soluble in hexane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.