Description

n-(tert-Butoxycarbonyl)Glycine-2-13C-15N is a stable isotope-labeled derivative of the amino acid glycine, specifically enriched with carbon-13 at the 2-position and nitrogen-15. This compound is essential for advanced research and development, providing a critical tool for precise metabolic and pharmacokinetic studies using mass spectrometry and NMR spectroscopy. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) engaged in drug discovery, proteomics, and biomarker research.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in bioanalytical method development for glycine and related compounds.
• Metabolic Pathway Tracing: Used in 13C and 15N tracer studies to elucidate biochemical pathways and flux analysis in cell cultures and animal models.
• Peptide Synthesis & Proteomics: Incorporated into isotopically labeled peptides for use as standards in quantitative proteomics (e.g., SIL, AQUA).
• NMR Spectroscopy: Provides a non-radioactive, sensitive probe for structural and dynamic studies of biomolecules.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables the accurate tracking of drug metabolites containing glycine moieties.
• Biomedical Research: Facilitates studies in areas such as cancer metabolism, neurotransmitter synthesis, and collagen research.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)Glycine-2-13C-15N
CAS No.	145143-01-7
Molecular Formula	C7H1313C15NO4
Molecular Weight	190.17 g/mol (for labeled form)
Synonyms	Boc-Glycine-2-13C-15N; N-Boc-Glycine-2-13C-15N; (tert-Butoxycarbonyl)glycine-2-13C-15N; 2-((tert-Butoxycarbonyl)amino)acetic-2-13C-15N acid; N-(tert-Butoxycarbonyl)-glycine-2-13C-15N; Boc-Gly-OH-2-13C-15N; Glycine-2-13C-15N, N-Boc-; N-Boc-glycine-2-13C,15N
EINECS	Contact for details

Quality Control

Every batch of our n-(tert-Butoxycarbonyl)Glycine-2-13C-15N is produced and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive analysis performed via NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing the assay, isotopic enrichment (atom % 13C and 15N), and impurity profile to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (15N)	≥ 98 atom %
Chemical Purity (NMR)	≥ 97%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.