Description

(1S 2R)-Ephedrine Hemihydrate 98 is a high-purity, stereochemically defined alkaloid compound. This specific enantiomer is valued for its precise pharmacological activity and serves as a critical chiral intermediate in advanced synthesis. It is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring consistent quality and reliable supply for regulated production processes.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) targeting adrenergic receptors.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in the production of enantiomerically pure compounds.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in regulatory laboratories.
• Research & Development: Employed in medicinal chemistry and pharmacological research for studying structure-activity relationships.
• Decongestant Formulations: A precursor in the controlled manufacturing of specific decongestant and bronchodilator medications.

Basic Information

Product Name	(1S 2R)-Ephedrine Hemihydrate 98
CAS No.	144429-10-7
Molecular Formula	C10H15NO · ½H2O
Molecular Weight	174.24 g/mol (anhydrous basis)
Synonyms	(-)-Ephedrine Hemihydrate; (1S,2R)-(-)-Ephedrine Hemihydrate; l-Ephedrine Hemihydrate; [R-(R*,S*)]-α-[1-(Methylamino)ethyl]benzenemethanol Hemihydrate; Erythro-(-)-Ephedrine Hemihydrate; 1R,2S-(-)-Ephedrine Hemihydrate; Ephedrine, (-)-, hemihydrate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our (1S 2R)-Ephedrine Hemihydrate 98 is manufactured under strict quality management systems. Each batch is tested to ensure it meets the declared 98% minimum purity and stringent limits for related substances. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and residual solvents is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to protect from humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1S,2R enantiomer)
Water Content (KF)	4.0% - 6.0% (theoretical for hemihydrate: ~5.2%)
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual unknown: ≤ 0.5%; Total: ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.