Description

Lithium Pyrrolidinoborohydride 1M Solution is a versatile and highly reactive borohydride reagent, specifically formulated as a 1.0 M solution in an organic solvent for precise handling and consistent performance. This compound is valued for its superior selectivity and reducing power compared to traditional hydride reagents, making it a critical tool in advanced synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the selective reduction of carbonyls, imines, and other functional groups.

Application

• Selective Carbonyl Reduction: A powerful and chemoselective reagent for the reduction of aldehydes and ketones in the presence of other sensitive functional groups.
• Asymmetric Synthesis: Employed as a key chiral reducing agent in the synthesis of enantiomerically pure pharmaceutical intermediates and active ingredients.
• Imine and Oxime Reduction: Effective for the conversion of imines and oximes to their corresponding amines, a crucial step in heterocycle and alkaloid synthesis.
• Process Chemistry & Scale-up: Used in pilot plant and manufacturing settings for the development of robust, scalable reduction steps in API (Active Pharmaceutical Ingredient) production.
• Polymer Chemistry: Acts as a modifying agent or initiator in specialized polymer synthesis and material science applications.
• Academic & Industrial R&D: A staple reagent in discovery chemistry for exploring novel synthetic pathways and creating complex molecular architectures.

Basic Information

Product Name	Lithium Pyrrolidinoborohydride 1M Solution
CAS No.	144188-76-1
Molecular Formula	C₄H₁₀BLiN
Molecular Weight	89.89 g/mol
Synonyms	Lithium Pyrrolidin-1-ylborohydride; Lithium 1-Pyrrolidinylborohydride; Lithium 1-Pyrrolidinylhydroborate; L-Selectride® (related commercial analog); Lithium Tri-sec-butylborohydride (related superhydride); Pyrrolidinoborohydride Lithium Salt; Borate(1-), hydro(pyrrolidinato)-, lithium, (T-4)-; Lithium Hydro(pyrrolidinato)borate(1-)
EINECS	Contact for details

Quality Control

Our Lithium Pyrrolidinoborohydride 1M Solution is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm concentration, purity, and the absence of critical impurities that could impact sensitive reactions. A comprehensive Certificate of Analysis (COA) detailing assay, solvent content, and identity confirmation is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) to maintain stability and potency. The solution is highly volatile, moisture-sensitive, and easily oxidized; therefore, it must be handled in a well-ventilated area using appropriate inert techniques (Schlenk line or glovebox) to prevent exposure to air and moisture.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Concentration	1.0 M in THF (or specified solvent)
Assay (Titration)	≥ 95.0%
Identification (IR)	Conforms to reference spectrum
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.