Description

Dmt-2'-Fluoro-Dg(Ib) Phosphoramidite is a high-purity, specialty phosphoramidite monomer used in the automated solid-phase synthesis of oligonucleotides. This compound is critical for introducing modified nucleosites into DNA/RNA sequences, enabling the creation of advanced research tools and therapeutic agents. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and diagnostic probe development.

Application

• Synthesis of Fluorine-Modified Oligonucleotides: Key building block for incorporating 2'-fluoro-deoxyguanosine analogs into DNA strands.
• Antisense & siRNA Therapeutic Development: Used to create oligonucleotides with enhanced nuclease resistance and binding affinity for drug discovery.
• Diagnostic Probe Manufacture: Essential for producing labeled probes and primers used in PCR, FISH, and other molecular diagnostic assays.
• Basic Nucleic Acid Research: Enables the study of structure-function relationships in modified nucleic acids.
• Aptamer and SELEX Technology: Used in the generation of nucleic acid libraries with modified bases for selecting high-affinity binders.
• Synthesis of Research-Grade Oligos: For contract research organizations (CROs) and core facilities providing custom oligonucleotide synthesis services.

Basic Information

Product Name	Dmt-2'-Fluoro-Dg(Ib) Phosphoramidite
CAS No.	144089-97-4
Molecular Formula	C41H49FN5O8P
Molecular Weight	797.84 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-F-dG(Ib) Phosphoramidite; 2'-Fluoro-2'-deoxyguanosine phosphoramidite; DMT-2'-F-dG(ib) CE Phosphoramidite; 2'-F-dG Phosphoramidite (Ib); Guanosine, 2'-deoxy-2'-fluoro-, 5'-[bis(4-methoxyphenyl)phenylmethyl] 3'-(2-cyanoethyl diisopropylphosphoramidite); 144089-97-4.
EINECS	Contact for details

Quality Control

Our Dmt-2'-Fluoro-Dg(Ib) Phosphoramidite is manufactured under strict quality systems to ensure consistency and reliability for critical synthesis applications. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis and 31P/1H NMR spectroscopy for structural confirmation and to verify the absence of critical impurities. Certificates of Analysis (COA) with full specification data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Moisture Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.