Description

Norvaline,5-Mercapto-,Methylester(9Ci) is a specialized sulfur-containing amino acid derivative, valued for its unique thiol functional group which makes it a versatile building block in organic synthesis and pharmaceutical research. This compound is particularly significant for the development of novel peptide-based therapeutics and enzyme inhibitors. It is primarily sought by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and advanced material science.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel peptide drugs and protease inhibitors.
• Bioconjugation Chemistry: Utilized for site-specific protein/antibody modification via its reactive thiol group.
• Chemical Biology Research: Serves as a precursor or probe in studying enzyme mechanisms and metabolic pathways.
• Ligand Synthesis: Used in the preparation of metal-chelating agents and catalysts for asymmetric synthesis.
• Protecting Group Strategy: The methyl ester and thiol functionalities allow for orthogonal protection/deprotection in complex multi-step syntheses.

Basic Information

Product Name	Norvaline,5-Mercapto-,Methylester(9Ci)
CAS No.	144073-03-0
Molecular Formula	C6H11NO2S
Molecular Weight	161.22 g/mol
Synonyms	5-Mercaptonorvaline Methyl Ester; L-5-Mercaptonorvaline Methyl Ester; (2S)-2-Amino-5-mercaptopentanoic acid methyl ester; Methyl (2S)-2-amino-5-mercaptopentanoate; 5-Thianorvaline methyl ester; Norvaline, 5-mercapto-, methyl ester, L-; 144073-03-0; Methyl 5-mercaptonorvalinate
EINECS	Contact for details

Quality Control

Our Norvaline,5-Mercapto-,Methylester(9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥95% by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation of the thiol group. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.