Description

Boc-(2S)-Indoline Carboxylic Acid CAS NO 144069-67-0 is a high-purity, enantiomerically pure chiral building block essential for modern organic synthesis. This compound is a critical intermediate in the development of active pharmaceutical ingredients (APIs) and complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid, bicyclic indoline scaffold into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a versatile starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral centers.
• Agrochemical Research: Employed in the development of novel herbicides and fungicides with specific stereochemical requirements.
• Chemical Biology Probes: Utilized for creating labeled or tagged molecular tools to study enzyme function and protein-protein interactions.
• Material Science: Potential monomer for the synthesis of specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	Boc-(2S)-Indoline Carboxylic Acid
CAS No.	144069-67-0
Molecular Formula	C₁₄H₁₇NO₄
Molecular Weight	263.29 g/mol
Synonyms	(2S)-1-[(1,1-Dimethylethoxy)carbonyl]-2,3-dihydro-1H-indole-2-carboxylic Acid; (S)-1-Boc-indoline-2-carboxylic Acid; (S)-1-(tert-Butoxycarbonyl)indoline-2-carboxylic Acid; Boc-L-Indoline-2-carboxylic Acid; (S)-1-N-Boc-indoline-2-carboxylic Acid; (S)-2-Carboxyindoline-1-carboxylic Acid tert-Butyl Ester; (S)-Indoline-2-carboxylic Acid N-Boc Derivative
EINECS	Contact for details

Quality Control

Our Boc-(2S)-Indoline Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards typical for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess (typically ≥99%), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.