Description

2-(4-Trifluoromethyl-Phenyl)-Thiazole-4-Carboxylic Acid is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. Its core value lies in the unique trifluoromethylphenyl-thiazole scaffold, which imparts desirable properties like metabolic stability and enhanced lipophilicity to target molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis or for constructing complex organic frameworks with specific electronic properties.
• Chemical Biology Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific heterocyclic carboxylic acid.

Basic Information

Product Name	2-(4-Trifluoromethyl-Phenyl)-Thiazole-4-Carboxylic Acid
CAS No.	144061-16-5
Molecular Formula	C11H6F3NO2S
Molecular Weight	273.23 g/mol
Synonyms	4-(Trifluoromethyl)phenyl-4-thiazolecarboxylic acid; 2-[4-(Trifluoromethyl)phenyl]-1,3-thiazole-4-carboxylic acid; 2-(4-Trifluoromethylphenyl)thiazole-4-carboxylic acid; 2-(4-Trifluoromethylphenyl)-4-thiazolecarboxylic acid; 2-(p-Trifluoromethylphenyl)thiazole-4-carboxylic acid; α-(4-Trifluoromethylphenyl)-4-thiazolecarboxylic acid; TFTCA (common abbreviation)
EINECS	Contact for details

Quality Control

Our 2-(4-Trifluoromethyl-Phenyl)-Thiazole-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.