Description

Piclamilast is a potent and selective phosphodiesterase 4 (PDE4) inhibitor, a key compound in pharmaceutical research and development. Its primary value lies in its targeted mechanism of action, making it a critical intermediate and reference standard for developing novel anti-inflammatory and immunomodulatory therapies. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on respiratory diseases, dermatological conditions, and other inflammatory disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced drug candidates targeting PDE4.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Biochemical Research: A vital tool for in vitro and in vivo studies to elucidate the role of PDE4 in cellular signaling pathways and disease models.
• Drug Discovery & Development: Employed in high-throughput screening and lead optimization programs for inflammatory and autoimmune diseases.
• Academic Research: Utilized by universities and research institutes for preclinical investigations into chronic obstructive pulmonary disease (COPD), psoriasis, and asthma.

Basic Information

Product Name	Piclamilast
CAS No.	144035-83-6
Molecular Formula	C₁₉H₁₇Cl₂N₃O₄
Molecular Weight	422.26 g/mol
Synonyms	3-Cyclopentyloxy-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; RP 73401; 3-Cyclopentyloxy-4-methoxy-N-(3,5-dichloro-4-pyridyl)benzamide; Benzamide, 3-cyclopentyloxy-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-; Piclamilast (RP 73401)
EINECS	Contact for details

Quality Control

Our Piclamilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.