Description

Creatinine-D3 is a stable isotope-labeled analog of creatinine, a critical biomarker for renal function. This high-purity deuterated standard is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily used by research institutions, clinical diagnostic laboratories, and pharmaceutical companies engaged in metabolomics, pharmacokinetic studies, and the development of in-vitro diagnostic (IVD) assays.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial quantitative reference in liquid chromatography-tandem mass spectrometry for precise measurement of endogenous creatinine levels in biological matrices like serum, plasma, and urine.
• Clinical Diagnostics & IVD Development: Used in the calibration and validation of diagnostic kits and automated clinical chemistry analyzers to ensure accurate assessment of kidney function (e.g., eGFR calculations).
• Metabolomics & Biomarker Research: Enables accurate profiling of creatinine in complex biological samples for disease mechanism studies and discovery of related metabolic biomarkers.
• Pharmaceutical & Preclinical Research: Applied in drug metabolism and pharmacokinetics (DMPK) studies to monitor renal clearance and potential nephrotoxicity of drug candidates.
• Forensic & Doping Control Analysis: Utilized as a reference standard in forensic toxicology and anti-doping controls to accurately normalize analyte concentrations and detect adulteration.
• Quality Control & Method Validation: Essential for developing, validating, and auditing analytical methods in compliance with guidelines from CLIA, CAP, and ISO 15189.

Basic Information

Item	Detail
Product Name	Creatinine-D3
CAS No.	143827-20-7
Molecular Formula	C4H4D3N3O
Molecular Weight	116.12 g/mol
Synonyms	2-Amino-1-methyl-4,5-dihydro-1H-imidazol-5-one-2,4,5-D3; Creatinine (methyl-D3); 1-Methylhydantoin-2-imine-4,5,5-D3; Deuterated Creatinine; Creatinine-d3; [2H3]-Creatinine; (Methyl-d3)creatinine; Stable Isotope Labeled Creatinine
EINECS	Contact for details

Quality Control

Every batch of Creatinine-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, isotopic enrichment, and absence of critical impurities. Our quality protocols are designed to meet the exacting standards required for research, diagnostic, and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.