Description

3-(tert-Butyldimethylsilyloxy)Pyrrolidine is a versatile organosilicon-protected pyrrolidine derivative, serving as a crucial chiral building block and protecting group reagent in advanced organic synthesis. Its primary value lies in enabling the selective protection of hydroxyl groups, facilitating complex multi-step reactions in the production of high-value fine chemicals and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of complex drug molecules, particularly those containing pyrrolidine or proline scaffolds.
• Asymmetric Synthesis: Used as a ligand or auxiliary in catalytic asymmetric reactions to induce chirality in target compounds.
• Amino Acid & Peptide Chemistry: Employed for the protection of hydroxyproline and other hydroxyl-containing amino acids during peptide synthesis.
• Natural Product Synthesis: Building block in the total synthesis of alkaloids and other natural products featuring pyrrolidine rings.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for functionalized polymers and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	3-(tert-Butyldimethylsilyloxy)Pyrrolidine
CAS No.	143656-87-5
Molecular Formula	C10H23NOSi
Molecular Weight	201.39 g/mol
Synonyms	3-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidine; 3-(Tert-butyldimethylsilyloxy)pyrrolidine; 3-(TBDMS-Oxy)pyrrolidine; 3-Hydroxypyrrolidine tert-butyldimethylsilyl ether; 3-(tert-Butyldimethylsiloxy)pyrrolidine; Pyrrolidin-3-ol, 1-(1,1-dimethylethyl)dimethylsilyl ether; TBDMS-protected 3-hydroxypyrrolidine
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyldimethylsilyloxy)Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.