Description

2,3,4,6-Tetra-o-Benzyl-α-D-Glucopyranosyl N,N,N',N'-Tetramethylphosphorodiamidate is a sophisticated glycosyl donor reagent, a key intermediate in the synthesis of complex oligosaccharides and glycoconjugates. Its value lies in its role as a phosphoramidite derivative, enabling highly efficient and stereoselective glycosylation reactions under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of carbohydrate-based drugs, vaccines, and diagnostic agents.

Application

• Oligosaccharide Synthesis: A critical building block for the automated and manual solid-phase synthesis of complex oligosaccharide chains.
• Glycoconjugate Production: Used in the preparation of glycoproteins, glycolipids, and neoglycoconjugates for biological studies and therapeutic applications.
• Pharmaceutical Intermediates: Serves as a key precursor in the development of carbohydrate-based active pharmaceutical ingredients (APIs) and prodrugs.
• Glycoscience Research: A fundamental tool in academic and industrial research exploring glycosylation mechanisms, enzyme inhibitors, and carbohydrate-protein interactions.
• Vaccine Development: Employed in the synthesis of carbohydrate antigens for conjugate vaccine candidates against bacterial pathogens.
• Diagnostic Reagents: Used to create labeled carbohydrate probes and arrays for diagnostic assays and biomarker discovery.

Basic Information

Product Name	2,3,4,6-Tetra-o-Benzyl-α-D-Glucopyranosyl N,N,N',N'-Tetramethylphosphorodiamidate
CAS No.	143520-19-8
Molecular Formula	C34H45N2O7P
Molecular Weight	624.70 g/mol
Synonyms	2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl N,N,N',N'-tetramethylphosphorodiamidate; α-D-Glucopyranosyl Phosphorodiamidate, 2,3,4,6-tetra-O-benzyl-, N,N,N',N'-tetramethyl-; Glucopyranosylphosphorodiamidate, tetra-O-benzyl-, tetramethyl-; Tetra-O-benzyl-D-glucopyranosyl tetramethylphosphorodiamidate; Glycosyl Phosphorodiamidate Donor; Benzyl-Protected Glucosyl Phosphoramidite; CAS 143520-19-8
EINECS	Contact for details

Quality Control

Our 2,3,4,6-Tetra-o-Benzyl-α-D-Glucopyranosyl N,N,N',N'-Tetramethylphosphorodiamidate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.