Description

2-Bromo-5-Trifluoromethylthiophene is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing sulfur-containing, fluorinated motifs into complex molecular architectures, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediates: A key synthon in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Active Ingredients: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursors: Serves as a monomer or building block for conductive polymers, organic semiconductors, and liquid crystals for electronic applications.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings for carbon-carbon bond formation.
• Functionalized Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and coordination chemistry.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on the reactivity and properties of thiophene-based systems.

Basic Information

Product Name	2-Bromo-5-Trifluoromethylthiophene
CAS No.	143469-22-1
Molecular Formula	C5H2BrF3S
Molecular Weight	230.03 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)thiophene; 5-(Trifluoromethyl)-2-bromothiophene; Thiophene, 2-bromo-5-(trifluoromethyl)-; 2-Bromo-α,α,α-trifluoro-5-thiophenemethanol (related); 2-Bromo-5-trifluoromethylthiophene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Trifluoromethylthiophene is produced and controlled under a strict quality management system. We provide comprehensive analytical data including HPLC purity, GC analysis, and 1H/19F NMR verification to ensure identity and consistency. Certificates of Analysis (COA) detailing all specifications are available for review and are supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.