Description

(3As,7Ar)-tert-Butyl 5-Oxooctahydro-1H-Indole-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and metabolic disorder targets.
• Process Chemistry: Used in the development and scale-up of synthetic routes for new chemical entities (NCEs) during clinical trial material production.
• Asymmetric Synthesis: Serves as a precursor for catalysts or ligands used in stereoselective reactions due to its defined stereocenters.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of lead compounds.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Product Name	(3As,7Ar)-tert-Butyl 5-Oxooctahydro-1H-Indole-1-Carboxylate
CAS No.	143268-07-9
Molecular Formula	C13H21NO3
Molecular Weight	239.31 g/mol
Synonyms	tert-Butyl (3aS,7aR)-5-oxooctahydro-1H-indole-1-carboxylate; (3aS,7aR)-1-Boc-5-oxo-octahydroindole; 1-Boc-5-oxo-(3aS,7aR)-octahydroindole; 1-(tert-Butoxycarbonyl)-5-oxo-(3aS,7aR)-octahydroindole; (3aS,7aR)-5-Oxo-hexahydro-1H-indole-1-carboxylic acid tert-butyl ester; BOC-Protected 5-oxo-octahydroindole (stereospecific); tert-Butyl (3aS,7aR)-5-oxoperhydroindole-1-carboxylate
EINECS	Contact for details

Quality Control

Our (3As,7Ar)-tert-Butyl 5-Oxooctahydro-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.