Description

5-Chloro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile and reactive scaffold for constructing complex nitrogen-containing heterocycles, which are prevalent in active pharmaceutical ingredients. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable, high-purity building block for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging the indole core for biological activity.
• Fine Chemical Building Block: Employed in the multi-step synthesis of complex organic molecules for material science and specialty chemistry applications.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new chemical spaces and reaction methodologies.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of manufacturing routes for active compounds.

Basic Information

Product Name	5-Chloro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	143262-12-8
Molecular Formula	C13H16ClNO2
Molecular Weight	253.72 g/mol
Synonyms	1-Boc-5-chloroindoline; 5-Chloro-2,3-dihydro-1H-indole-1-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 5-chloro-2,3-dihydro-1H-indole-1-carboxylate; 5-Chloroindoline-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-5-chloroindoline; Boc-5-chloroindoline; 5-Chloro-N-Boc-indoline
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.