Description

1-Boc-Indoline is a high-purity, protected indoline derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile nitrogen-protected scaffold for constructing complex heterocyclic molecules and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries, enabling the synthesis of novel compounds with enhanced biological activity and stability.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of drug candidates, particularly those containing indoline or related heterocyclic cores.
• Organic Synthesis Reagent: Used as a protected amine precursor in multi-step synthesis, including peptide coupling and cross-coupling reactions.
• Agrochemical Research: Intermediate for developing novel pesticides and herbicides with specific biological targets.
• Material Science: Precursor for functionalized polymers and advanced organic materials requiring specific nitrogen-containing motifs.
• Academic & R&D: Fundamental reagent in medicinal chemistry research for exploring new chemical entities and structure-activity relationships (SAR).

Basic Information

Product Name	1-Boc-Indoline
CAS No.	143262-10-6
Molecular Formula	C₁₃H₁₇NO₂
Molecular Weight	219.28 g/mol
Synonyms	1-tert-Butoxycarbonylindoline; tert-Butyl 2,3-dihydro-1H-indole-1-carboxylate; N-Boc-indoline; 1-N-Boc-indoline; Indoline-1-carboxylic acid tert-butyl ester; Boc-Indoline; N-(tert-Butoxycarbonyl)indoline; 1-(tert-Butoxycarbonyl)indoline
EINECS	Contact for details

Quality Control

Our 1-Boc-Indoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.