Description

3-Bromoindole-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-purity indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in enabling the efficient construction of complex heterocyclic scaffolds, particularly in the development of novel active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key protected precursor for the synthesis of indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators that leverage the indole core structure.
• Organic Synthesis Building Block: Facilitates palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other functional group transformations due to the reactive bromine substituent.
• Material Science Precursor: Employed in the research of organic electronic materials and functional dyes where the indole moiety is integral.
• Academic & Contract Research: Serves as a standard reagent in university laboratories and CROs (Contract Research Organizations) for methodological studies and library synthesis.

Basic Information

Product Name	3-Bromoindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	143259-56-7
Molecular Formula	C13H14BrNO2
Molecular Weight	296.16 g/mol
Synonyms	1-BOC-3-Bromoindole; tert-Butyl 3-Bromo-1H-indole-1-carboxylate; 3-Bromo-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 3-Bromoindole-1-carboxylic acid 1,1-dimethylethyl ester; 3-Bromo-1-(tert-butoxycarbonyl)indole; 1-Boc-3-bromo-1H-indole; 3-Bromo-1-Boc-indole; 3-Bromo-N-Boc-indole
EINECS	Contact for details

Quality Control

Our 3-Bromoindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.