Description

2-(Bromomethyl)-5-Fluorobenzothiazole is a versatile and high-value fluorinated benzothiazole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its dual functionalization, featuring a reactive bromomethyl group and a fluorine atom, which enables precise molecular construction for complex target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science Research: Used in the creation of fluorinated organic semiconductors, liquid crystals, and advanced polymers.
• Fluorescent Probe Development: Serves as a core structure for synthesizing benzothiazole-based fluorescent dyes and sensors.
• Cross-Coupling Reactions: The bromomethyl group facilitates Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Ligand and Catalyst Design: Intermediate for preparing novel nitrogen-sulfur containing ligands used in asymmetric catalysis.

Basic Information

Product Name	2-(Bromomethyl)-5-Fluorobenzothiazole
CAS No.	143163-70-6
Molecular Formula	C8H5BrFNS
Molecular Weight	246.10 g/mol
Synonyms	5-Fluoro-2-(bromomethyl)benzothiazole; 2-Bromomethyl-5-fluorobenzothiazole; 5-Fluoro-2-bromomethylbenzothiazole; 2-(Bromomethyl)-5-fluoro-1,3-benzothiazole; 143163-70-6; 5-Fluoro-2-(bromomethyl)-1,3-benzothiazole; 2-Bromomethyl-5-fluoro-benzo[d]thiazole
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-5-Fluorobenzothiazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.