Description

(R)-2-((R)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Propan-1-Ol CAS NO 142976-45-2 is a high-purity chiral intermediate characterized by its specific stereochemistry and tetrahydroisoquinoline core structure. This compound is critical for the synthesis of complex pharmaceutical molecules, particularly those targeting neurological and cardiovascular pathways. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure drugs, including potential β-blockers, adrenergic agents, and other central nervous system (CNS) active compounds.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high optical purity.
• Medicinal Chemistry Research: Serves as a crucial scaffold in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Used in scaling up synthetic routes for APIs, where consistent stereochemical integrity is paramount.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals requiring the tetrahydroisoquinoline motif.

Basic Information

Item	Detail
Product Name	(R)-2-((R)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Propan-1-Ol
CAS No.	142976-45-2
Molecular Formula	C₁₄H₂₁NO₃
Molecular Weight	251.32 g/mol
Synonyms	(1R)-1-[(1R)-2-Hydroxypropyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; (R,R)-6,7-Dimethoxy-1-(1-hydroxypropan-2-yl)-1,2,3,4-tetrahydroisoquinoline; (R)-2-((R)-6,7-Dimethoxy-1,2,3,4-tetrahydro-1-isoquinolinyl)-1-propanol; (R,R)-THIQ Propanol Derivative; Chiral Tetrahydroisoquinoline Alcohol; (R,R)-DMTIQ-OH; (1R,1'R)-1-(1'-Hydroxypropyl)-6,7-dimethoxytetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (R)-2-((R)-6,7-Dimethoxy-1,2,3,4-Tetrahydro-Isoquinolin-1-Yl)-Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.