Description

1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-6-Methoxy-,1,1-Dimethylethyl Ester,(S)- (9Ci) is a chiral, non-racemic synthetic intermediate of significant value in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by research and development chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sophisticated heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, including potential central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (S)-configured tetrahydroisoquinoline moiety into target molecules.
• Medicinal Chemistry Research: Serves as a scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and high-throughput screening.
• Agrochemical Development: Used in the synthesis of advanced, chiral active ingredients for crop protection products.
• Catalyst and Ligand Preparation: Can be employed as a precursor for developing novel chiral ligands or organocatalysts.
• Academic and Institutional Research: A valuable reagent for methodological studies in organic chemistry and total synthesis projects.

Basic Information

Product Name	1-Isoquinolineacetic Acid,1,2,3,4-Tetrahydro-6-Methoxy-,1,1-Dimethylethyl Ester,(S)- (9Ci)
CAS No.	142801-72-7
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	(S)-tert-Butyl 2-(6-methoxy-1,2,3,4-tetrahydro-1-isoquinolyl)acetate; (S)-1,2,3,4-Tetrahydro-6-methoxy-1-isoquinolineacetic Acid 1,1-Dimethylethyl Ester; (S)-6-Methoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic Acid tert-Butyl Ester; tert-Butyl (S)-2-(6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate; (S)-TB-6-Methoxy-THIQAA; (S)-Tert-Butyl 6-Methoxytetrahydroisoquinoline-1-acetate; (S)-1-(tert-Butoxycarbonylmethyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), with specifications tailored for research and process development use. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request. Our quality system supports development under cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in a compatible environment for strong acid/organic solvent. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.