Description

5-Bromo-3-Iodo-1-Tosyl-1H-Indole is a highly functionalized indole derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in the strategic placement of halogen and sulfonyl groups, which serve as versatile handles for further cross-coupling and functionalization reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel indole-based drug candidates, particularly in oncology and CNS research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the indole core structure.
• Material Science: Acts as a precursor for organic electronic materials and functional dyes due to its electron-rich indole system and modifiable substituents.
• Cross-Coupling Reactions: The bromo and iodo groups are excellent substrates for Suzuki, Stille, and Sonogashira couplings to create complex molecular architectures.
• Chemical Biology: Utilized as a probe or linker in bioconjugation chemistry and the development of molecular tools.
• Academic & R&D: A valuable reagent for methodological studies in synthetic organic chemistry and catalysis.

Basic Information

Product Name	5-Bromo-3-Iodo-1-Tosyl-1H-Indole
CAS No.	142688-28-6
Molecular Formula	C15H11BrINO2S
Molecular Weight	492.13 g/mol
Synonyms	1H-Indole, 5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]- 5-Bromo-3-iodo-1-(p-toluenesulfonyl)indole 5-Bromo-3-iodo-1-tosylindole 5-Br-3-I-1-Ts-indole 1-Tosyl-5-bromo-3-iodoindole 142688-28-6 N-Tosyl-5-bromo-3-iodoindole
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-1-Tosyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.