Description

n-(2-(2-Phthalimidoethoxy)Acetyl)-L-Alanyl-D-Glutamic Acid is a specialized synthetic peptide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or building block for the synthesis of more complex peptide-based therapeutics and diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel drugs, particularly in areas requiring specific chiral and structural modifications. The high purity and precise stereochemistry of this material are essential for ensuring the efficacy and safety of the final pharmaceutical products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development and study of enzyme inhibitors targeting specific proteolytic pathways.
• Conjugate Chemistry: Serves as a linker or spacer molecule in the creation of antibody-drug conjugates (ADCs) or other bioconjugates.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug candidate properties.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic assays and biochemical studies.
• Custom Peptide Synthesis: A critical component for contract research organizations (CROs) and CDMOs producing custom peptides for clients.

Basic Information

Product Name	n-(2-(2-Phthalimidoethoxy)Acetyl)-L-Alanyl-D-Glutamic Acid
CAS No.	142489-47-2
Molecular Formula	C20H22N4O9
Molecular Weight	462.41 g/mol
Synonyms	N-[2-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]acetyl]-L-alanyl-D-glutamic acid; L-Alanine, N-[2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]acetyl]-, (R)-; N-(2-(2-Phthalimidoethoxy)acetyl)-L-alanyl-D-glutamic acid; PG 1002; PG-1002; Phthalimidoethoxyacetyl-Ala-Glu; Phthalimido-PEG2-Ala-Glu; Phthalimidoethyleneglycolacetyl-Ala-Glu
EINECS	Contact for details

Quality Control

Our n-(2-(2-Phthalimidoethoxy)Acetyl)-L-Alanyl-D-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.