Description

Cycloviracin B2 is a naturally derived cyclic lipopeptide antibiotic with potent antifungal activity, primarily isolated from Streptomyces species. It is valued in pharmaceutical research for its selective inhibition of fungal cell wall synthesis and low mammalian cytotoxicity. Researchers and biopharmaceutical developers use Cycloviracin B2 CAS NO 142382-46-5 for antifungal mechanism studies, lead compound optimization, and preclinical evaluation of novel antimycotic agents.

Application

• Antifungal drug discovery and structure–activity relationship (SAR) studies
• Reference standard in HPLC and LC-MS quantification of lipopeptide antibiotics
• In vitro evaluation of synergistic effects with azoles or echinocandins against Candida and Aspergillus strains
• Tool compound for investigating fungal membrane integrity and chitin biosynthesis pathways
• Quality control reference material for fermentation-derived antifungal APIs
• Biological assay calibration in high-throughput screening (HTS) platforms targeting fungal virulence factors
• Stability-indicating method development for lipopeptide formulations
• Academic and industrial research on resistance mechanisms in pathogenic fungi

Basic Information

Product Name	Cycloviracin B2
CAS No.	142382-46-5
Molecular Formula	C50H79N11O14
Molecular Weight	1066.23 g/mol
Synonyms	Cycloviracin B2; Cycloviracin-B2; CVB2; Antibiotic CVB2; Streptomyces-derived cyclic lipopeptide B2; Cycloviracin BII; Cycloviracin B-2; Lipopeptide antibiotic Cycloviracin B2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q5, Q6, and Q7 guidelines for biologically derived active pharmaceutical ingredients. Assay, residual solvents, heavy metals, endotoxin levels, and microbial limits are verified using validated methods including HPLC, LC-MS, and ICP-MS. Testing conforms to USP & EP monograph requirements for peptide antibiotics where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain in a low-humidity environment (<30% RH) with desiccant. Avoid repeated exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Related Substances (HPLC)	≤3.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤5.0%
Heavy Metals	≤10 ppm
Endotoxins	≤0.5 EU/mg
Microbial Contamination	Complies with USP <71>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.