Description

Cizolirtine is a selective, non-opioid analgesic agent that functions as a potent and specific agonist for the I2-imidazoline receptor. This compound is significant for its potential in developing novel pain management therapies that avoid the side effects and dependency risks associated with traditional opioid medications. It is primarily required by pharmaceutical research and development organizations, as well as academic institutions, for preclinical studies and the synthesis of new chemical entities targeting neuropathic and chronic pain pathways.

Application

• Pharmaceutical Research: A key intermediate or reference standard in the development of novel non-opioid analgesic drugs.
• Preclinical Studies: Used in pharmacological research to investigate I2-imidazoline receptor-mediated pathways and mechanisms of action.
• Chemical Synthesis: Serves as a crucial building block for the synthesis of more complex molecules with potential analgesic activity.
• Biochemical Assays: Employed as a ligand in receptor binding studies and selectivity profiling assays.
• Academic Research: Utilized in university and institutional labs for neuroscience and pain mechanism research.
• Analytical Reference: Acts as a high-purity standard for method development and validation in analytical chemistry (HPLC, LC-MS).

Basic Information

Product Name	Cizolirtine
CAS No.	142155-43-9
Molecular Formula	C15H17N3O2S
Molecular Weight	303.38 g/mol
Synonyms	2-(2-Benzofuranyl)-2-imidazoline; LNP 509; LNP-509; 2-(1-Benzofuran-2-yl)-4,5-dihydro-1H-imidazole; Cizolirtine Citrate (salt form precursor); (RS)-2-(2-Benzofuranyl)-2-imidazoline; 2-(Benzofuran-2-yl)-4,5-dihydro-1H-imidazole
EINECS	Contact for details

Quality Control

Our Cizolirtine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), residual solvents, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.