Description

Dihydro Montelukast Sodium Salt is a high-purity pharmaceutical intermediate and reference standard, chemically related to the active ingredient in leukotriene receptor antagonist medications. This compound is critical for research and development in respiratory pharmacology, particularly for studying metabolic pathways and developing analytical methods. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of asthma and allergy therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis and research of advanced leukotriene receptor antagonists.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical manufacturing to ensure product purity and consistency.
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway research related to montelukast and its derivatives.
• Impurity Profiling: Serves as a critical standard for identifying and quantifying related substances and degradation products in active pharmaceutical ingredient (API) batches.
• Academic & Clinical Research: Supports investigative studies into the mechanisms of leukotrienes and their role in inflammatory respiratory conditions.

Basic Information

Product Name	Dihydro Montelukast Sodium Salt
CAS No.	142147-98-6
Molecular Formula	C35H35ClNNaO3S
Molecular Weight	608.17 g/mol
Synonyms	Montelukast Dihydro Sodium Salt; Sodium 2-[1-[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropylacetate; Dihydro Montelukast Na Salt; 142147-98-6; MK-0476 Dihydro Sodium Salt
EINECS	Contact for details

Quality Control

Our Dihydro Montelukast Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identification by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.