Description

Oliceridine is a novel, synthetic opioid analgesic with a unique mechanism of action, designed to provide potent pain relief with an improved safety profile. This pharmaceutical active ingredient is significant for its selective agonism at the μ-opioid receptor, which is associated with a potentially lower incidence of respiratory depression and gastrointestinal side effects compared to traditional opioids. It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development of next-generation pain management therapies, including those for postoperative and chronic pain. Oliceridine CAS NO 142128-57-2 represents a targeted advancement in the critical field of non-addictive analgesic research.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable analgesic medications for hospital use.
• Postoperative Pain Management: Development of fast-acting solutions for the control of moderate-to-severe acute pain following surgical procedures.
• Chronic Pain Research: A key compound in preclinical and clinical studies investigating new paradigms for managing persistent pain conditions.
• Analgesic Mechanism Studies: Used as a reference standard in pharmacological research to study G protein-biased μ-opioid receptor signaling.
• Drug Delivery System Development: Incorporated into research on advanced controlled-release or targeted delivery platforms for opioids.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	Oliceridine
CAS No.	142128-57-2
Molecular Formula	C₂₄H₃₅NO₄
Molecular Weight	401.54 g/mol
Synonyms	TRV130; Olinvyk; (3-methoxythiophen-2-yl)methyl 1-[(2R,5S)-4-prop-2-enyl-2,5-dimethylpiperazin-1-yl]-3-(thiophen-3-yl)propan-1-one; 1-[(2R,5S)-4-Allyl-2,5-dimethyl-1-piperazinyl]-3-(3-thienyl)-1-propanone 2-(3-Methoxy-2-thienyl)methyl ether; 1-[(2R,5S)-4-(2-Propen-1-yl)-2,5-dimethyl-1-piperazinyl]-3-(3-thienyl)-1-propanone 2-[(3-Methoxy-2-thienyl)methyl] ether
EINECS	Contact for details

Quality Control

Our Oliceridine is manufactured under strict cGMP conditions to ensure the highest standards of purity and consistency required for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as identity, assay, purity, and specified impurities. We adhere to relevant ICH guidelines and can support customer-specific validation protocols. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.