Description

2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol is a versatile organosilicon-protected alcohol intermediate, crucial for its role in synthetic organic chemistry. This compound matters because it provides a robust protecting group for hydroxyl functions, enabling selective reactions in complex multi-step syntheses. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and fine chemical producers for the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly where selective protection of alcohol groups is required.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its stability under various reaction conditions is advantageous.
• Peptide Chemistry: Employed for the temporary protection of serine or threonine side chains during solid-phase or solution-phase peptide synthesis.
• Natural Product Synthesis: Facilitates the construction of complex natural products like macrolides and polyethers by protecting specific hydroxyl sites.
• Polymer Modification: Serves as a functional monomer or chain-transfer agent in the synthesis of specialty silicones and functional polymers.
• Cross-Coupling Reactions: Acts as a precursor for organometallic reagents used in palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol
CAS No.	142072-07-9
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	1-Propanol, 2-[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 2-[(tert-Butyldimethylsilyl)oxy]-1-propanol; 2-(TBDMSO)-1-propanol; 2-(tert-Butyldimethylsiloxy)propan-1-ol; 2-Hydroxypropyl tert-butyldimethylsilyl ether; TBDMS-protected 1,2-propanediol monoether; 2-O-TBDMS-1-propanol
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyl-Dimethyl-Silanyloxy)-Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.