Description

4-Methyl-D-Tryptophan is a high-purity, non-natural stereoisomer of the essential amino acid tryptophan, distinguished by a methyl group at the 4-position of the indole ring. This specific chiral configuration makes it a valuable building block and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications requiring precise molecular chirality and structural specificity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel therapeutic agents, particularly in neurology and oncology research.
• Biochemical Research: Used as a probe or substrate in enzymatic studies and metabolic pathway investigations due to its modified indole structure.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) and enhance peptide stability or bioavailability.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in analytical laboratories.
• Metabolite Analog: Employed in metabolic studies to investigate tryptophan metabolism and related biochemical processes.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in the synthesis of complex, enantiomerically pure molecules.

Basic Information

Product Name	4-Methyl-D-Tryptophan
CAS No.	141979-69-3
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.25 g/mol
Synonyms	(R)-2-Amino-3-(4-methyl-1H-indol-3-yl)propanoic acid; D-4-Methyltryptophan; (R)-4-Methyltryptophan; 4-Methyl-D-trp; 4-Me-D-Trp-OH; 4-Methyl-(R)-tryptophan; 4-Methyl-DL-tryptophan (related, but racemic)
EINECS	Contact for details

Quality Control

Our 4-Methyl-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.