Description

Ciclesonide CAS NO 141845-82-1 is a non-halogenated, topically active corticosteroid prodrug used as an anti-inflammatory agent. It is a critical active pharmaceutical ingredient (API) valued for its high local activity and low systemic bioavailability, which enhances its therapeutic safety profile. This compound is essential for pharmaceutical manufacturers developing advanced inhalation therapies, primarily for the treatment of asthma and allergic rhinitis.

Application

• Primary Pharmaceutical Ingredient: Core API in pressurized metered-dose inhalers (pMDIs) and dry powder inhalers (DPIs) for asthma management.
• Respiratory Therapeutics: Formulation into nasal sprays for the treatment of allergic and perennial rhinitis.
• Drug Development: Used in preclinical and clinical research for investigating new delivery systems for pulmonary and intranasal corticosteroids.
• Generic Pharmaceutical Manufacturing: Sourcing for the production of generic and branded pharmaceutical products containing ciclesonide.
• Contract Manufacturing: Supply to CDMOs (Contract Development and Manufacturing Organizations) for finished dosage form production.

Basic Information

Product Name	Ciclesonide
CAS No.	141845-82-1
Molecular Formula	C32H44O7
Molecular Weight	540.70 g/mol
Synonyms	Alvesco; Ciclesonidum; (11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione; 16α,17-[(Cyclohexylmethylene)bis(oxy)]-11β-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione; RPR 251526; ZK 345186; Cyclenil; Omnaris
EINECS	Contact for details

Quality Control

Our Ciclesonide is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines and relevant pharmacopoeial standards. Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and regulatory support for your pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.