Description

4-Bromo-2-(trifluoromethyl)thiazole is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for introducing the thiazole core along with halogen and fluorine functionalities into target molecules, enabling the fine-tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiazole ring and fluorine atoms contribute to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized materials, including liquid crystals, organic semiconductors, and ligands for catalysis.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Fluorine Chemistry Building Block: The CF3 group provides a source of fluorine, which is critical for modulating the physicochemical properties of lead compounds in drug discovery.

Basic Information

Product Name	4-Bromo-2-(trifluoromethyl)thiazole
CAS No.	141761-77-5
Molecular Formula	C4HBrF3NS
Molecular Weight	232.02 g/mol
Synonyms	2-(Trifluoromethyl)-4-bromothiazole; 4-Bromo-2-trifluoromethylthiazole; Thiazole, 4-bromo-2-(trifluoromethyl)-; 4-Bromo-2-(trifluoromethyl)-1,3-thiazole; 141761-77-5; 4-Bromo-2-(trifluoromethyl)thiazole
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2-(trifluoromethyl)thiazole adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive analytical data including HPLC/GC purity, NMR (1H, 13C, 19F), and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch and supplied with your order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.