Description

5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Ribofuranose is a key protected ribofuranose derivative, serving as a critical chiral building block in sophisticated organic synthesis. Its primary value lies in providing a highly versatile and reactive scaffold for the controlled construction of nucleoside analogs and other complex bioactive molecules. This high-purity intermediate is essential for research and development in pharmaceutical chemistry, particularly for antiviral and anticancer drug discovery programs.

Application

• Nucleoside & Nucleotide Synthesis: A pivotal precursor for the synthesis of modified nucleosides, including antiviral and anticancer agents.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic compounds, especially those targeting RNA viruses.
• Carbohydrate Chemistry: Serves as a protected sugar donor in glycosylation reactions for constructing complex oligosaccharides.
• Pro-drug Development: Utilized to create masked or targeted versions of active pharmaceutical ingredients to improve bioavailability or reduce side effects.
• Chemical Biology Probes: Acts as a starting material for synthesizing labeled or tagged nucleosides used in mechanistic studies and diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent in laboratories focused on medicinal chemistry and synthetic methodology development.

Basic Information

Item	Detail
Product Name	5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Ribofuranose
CAS No.	141607-35-4
Molecular Formula	C24H32O5Si
Molecular Weight	428.60 g/mol
Synonyms	1,2-O-Isopropylidene-5-O-(tert-butyldiphenylsilyl)-α-D-ribofuranose; 5-O-TBDPS-2,3-O-isopropylidene-D-ribofuranose; 5-O-(tert-Butyldiphenylsilyl)-1,2-O-isopropylidene-α-D-ribofuranose; TBDPS-protected isopropylidene ribose; D-Ribofuranose, 5-O-[1,1-dimethylethyl)diplenylsilyl]-2,3-O-(1-methylethylidene)-; Protected D-ribofuranose derivative
EINECS	Contact for details

Quality Control

Our 5-o-tert-Butyldiphenylsilyl-2,3-o-Isopropylidene-D-Ribofuranose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and optical rotation analysis, to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.